The Single Exposure Carcinogen Database: assessing the circumstances under which a single exposure to a carcinogen can cause cancer
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چکیده
منابع مشابه
DNA methylation: a marker for carcinogen exposure and cancer risk.
Cancers arise as a consequence of multiple genetic and epigenetic alterations. Many genes aberrantly methylated in cancers have been identified in recent years, and their use in cancer diagnosis and therapy is currently under investigation. During our genome-wide screening for a novel tumor-suppressor gene in gastric cancers, we found that only a small amount of aberrant methylation was present...
متن کاملNicotine, carbon monoxide, and carcinogen exposure after a single use of a water pipe.
BACKGROUND Smoking tobacco preparations in a water pipe (hookah) is widespread in many places of the world, including the United States, where it is especially popular among young people. Many perceive water pipe smoking to be less hazardous than cigarette smoking. We studied systemic absorption of nicotine, carbon monoxide, and carcinogens from one water pipe smoking session. METHODS Sixteen...
متن کاملOccupational carcinogen exposure in Canada.
My colleague Professor John Cherrie once said that we know more about the number of birds breeding in British meadows each year (see http://jncc.defra. gov.uk/pdf/BBSreport12_web.pdf) than the number of workers exposed to carcinogens in the workplace. It is clearly important to monitor bird populations, but I would consider it of at least equal importance to know what hazardous agents workers a...
متن کاملCAREX Canada: an enhanced model for assessing occupational carcinogen exposure
OBJECTIVES To estimate the numbers of workers exposed to known and suspected occupational carcinogens in Canada, building on the methods of CARcinogen EXposure (CAREX) projects in the European Union (EU). METHODS CAREX Canada consists of estimates of the prevalence and level of exposure to occupational carcinogens. CAREX Canada includes occupational agents evaluated by the International Agenc...
متن کاملCarcinogen exposure and gene promoter hypermethylation in bladder cancer.
Tobacco smoking, certain occupational exposures, and exposure to inorganic arsenic in drinking water have been associated with the occurrence of bladder cancer. However, in these tumors the exposure-associated pattern of somatic alterations in genes in the causal pathway for disease has been poorly characterized. In particular, the mechanism by which arsenic induces bladder cancer and the effec...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1999
ISSN: 1096-0929
DOI: 10.1093/toxsci/50.2.169